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KMID : 0380319920500000093
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Journal of Korean Research Institute for Better Living
1992 Volume.50 No. 0 p.93 ~ p.104
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The Polymorphisms of Serum α-1 Acid Glycoprotein and α-1 Antitrypsin in Korean Population
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Abstract
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Genetic polymophisms of two serum proteins, α-1 acid glycoprotein(ORM) and α-1 antitrypsin(Pi) in Korean population were studied by vertical polyacrylamide gel isoelectrofocusing.
The results were as follows ;
1. ORM has two alleles, ORM*1 and ORM*2. The phenotypes were found to be ORM 1, ORM 2 and ORM 2-1 in Korean population.
2. The gene frequencies of ORM alleles in sera were calculated to be 0.8045 for ORM*1 and 0.1955 for ORM*2.
3. There were at least twenty alleles in Pi so far. But only three alleles, PiM*1, PiM*2 and PiM*3 were found in this study.
4. piM phenotypes were found to be PiM1M1, PiM1M2, PiM1M3, PiM2M2, PiM2M3 and piM3M3 in Korean population.
5. The gene frequencies of PiM alleles were calculated to be piM*1=0.7651, PiM*2=0.1737 and PiM*3=0.0612.
6. Based on the above results, ORM and pi are polymorphic traits in Korean population.
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